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Growth in Infants with Cow's Milk Protein Allergy Fed an Amino Acid-Based Formula

Yvan Vandenplas1, Christophe Dupont2, Philippe Eigenmann3

  • 1Kidz Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Pediatric Gastroenterology, Hepatology & Nutrition
|July 28, 2021
PubMed

Insights

An amino acid-based formula (AAF) supported normal growth in infants with cow's milk protein allergy (CMPA). This formula, combined with a CMP-free diet, ensured healthy development until nine months of age.

Area of Science:

  • Pediatric Nutrition
  • Allergy Research
  • Infant Growth and Development

Background:

  • Cow's milk protein allergy (CMPA) is a common condition in infants, necessitating specialized dietary management.
  • Early diagnosis and appropriate nutritional support are crucial for managing CMPA and ensuring healthy infant growth.
  • Amino acid-based formulas (AAF) are often used for infants with severe or multiple food protein allergies.

Purpose of the Study:

  • To evaluate the efficacy of an amino acid-based formula (AAF) in supporting the growth of infants diagnosed with cow's milk protein allergy (CMPA).
  • To assess the long-term growth outcomes (weight, length, head circumference) of infants with CMPA managed with AAF up to nine months of age.

Main Methods:

  • A cohort of non-breastfed infants aged 0-6 months with suspected CMPA in China were enrolled.
  • Infants received AAF for two weeks, followed by an open food challenge (OFC) with cow's milk-based formula (CMF).
  • Confirmed CMPA cases were managed with AAF and a CMP-free complementary diet until nine months, with growth parameters (weight, length, head circumference) Z-scores assessed against WHO standards.

Main Results:

  • Out of 254 infants, 218 (85.8%) were diagnosed with non-IgE-mediated CMPA.
  • Infants fed AAF showed significant catch-up weight-for-age Z-score (WAZ) from enrollment to nine months (p=0.012).
  • No significant changes in length-for-age Z-score (LAZ) or head circumference-for-age Z-score (HCAZ) were observed, indicating normal linear and head growth velocity.

Conclusions:

  • The amino acid-based formula, alongside a CMP-free complementary diet, effectively supported normal growth in Chinese infants with confirmed non-IgE-mediated CMPA until nine months of age.
  • AAF is a viable nutritional option for promoting healthy growth in infants diagnosed with CMPA.
  • The study highlights the importance of appropriate formula selection for managing CMPA and ensuring optimal infant development.
Abstract

Keywords:
AnthropometryChallenge testFood hypersensitivityInfant formulaNutrition

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