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Major Somatic Sensory Pathways01:28

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Cerebellum: Anatomical Regions01:17

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The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
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Correction: Deep brain stimulation for Parkinson's disease in India: an expert consensus on availability, affordability, and eligibility by the Parkinson's research alliance India (PRAI).

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Related Experiment Video

Updated: Oct 26, 2025

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
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Treatable cerebellar ataxias.

Divya K P1, Asha Kishore1

  • 1Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala 695011, India.

Clinical Parkinsonism & Related Disorders
|July 28, 2021
PubMed
Summary

Cerebellar ataxic syndrome has many causes, some treatable. Early diagnosis via clinical history, examination, and investigation leads to better outcomes with targeted therapies.

Keywords:
Acute ataxiaCerebellar ataxiaGenetic ataxiaTreatable ataxia

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Area of Science:

  • Neurology
  • Genetics
  • Immunology

Background:

  • Cerebellar ataxic syndrome encompasses diverse genetic and acquired disorders.
  • Identifying treatable causes, including metabolic, immune-mediated, inflammatory, and hereditary conditions, offers significant patient and physician relief.

Purpose of the Study:

  • To review diseases presenting as cerebellar ataxia that are amenable to targeted therapies.
  • To highlight the importance of early diagnosis and treatment for favorable outcomes.

Main Methods:

  • The review discusses diseases based on their presentation as cerebellar ataxia.
  • Diagnostic approaches emphasize thorough clinical history, meticulous examination, and investigative strategies.

Main Results:

  • A pragmatic diagnostic algorithm for treatable ataxia is outlined.
  • Novel diagnostic techniques and targeted therapies are crucial for managing these conditions.

Conclusions:

  • Early diagnosis and prompt treatment of treatable cerebellar ataxic syndromes can lead to improved patient outcomes.
  • A systematic approach to diagnosis is essential for identifying treatable causes.