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Diffuse cortical calcification in rejected renal transplants.

R B Harrison, E D Vaughan

    Radiology
    |March 1, 1978
    PubMed
    Summary
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    Diffuse cortical calcification can occur in rejected renal transplants. This condition is now recognized alongside bilateral renal cortical necrosis and chronic glomerulonephritis as a cause of widespread kidney calcification.

    Area of Science:

    • Nephrology
    • Pathology
    • Radiology

    Background:

    • Diffuse cortical calcification is a rare finding in kidney disease.
    • Established causes include bilateral renal cortical necrosis and chronic glomerulonephritis.

    Observation:

    • Two cases of diffuse cortical calcification were identified in patients with rejected renal transplants.
    • Imaging findings and pathological specimens confirmed the calcification pattern.

    Findings:

    • Rejected renal transplants represent a newly identified cause of diffuse cortical calcification.
    • The study discusses potential pathophysiological mechanisms contributing to this calcification.

    Implications:

    • This finding expands the differential diagnosis for diffuse cortical calcification.

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  • Understanding the mechanisms may inform future management strategies for transplant recipients.