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Updated: Oct 26, 2025

A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
Published on: February 14, 2022
Multiple Interventional Procedures as an Alternative to Cardiac Transplantation
Katrien Blanchart1, Eric Saloux1, Remi Sabatier1
1Department of Cardiology, Caen University Hospital, Caen, France.
Abstract:
Heart failure (HF) is an increasing pandemic affecting more than 26 million people worldwide. Despite growing therapeutic options, the outlook of patients with HF remains particularly poor with high mortality and rehospitalization rates. When HF remains uncontrolled despite optimal medical therapy, mechanical circulatory devices or heart transplantation must be considered. Unfortunately, these therapeutic options are limited. This case explains how consecutive minimally invasive treatment allowed stabilization of end-stage HF thereby avoiding heart transplantation or mechanical assist devices. (Level of Difficulty: Intermediate.).
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