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Updated: Oct 26, 2025

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Refractory In-Stent Restenosis Attributable to Eruptive Calcified Nodule

Hiroki Nakano1,2, Yu Kataoka1, Fumiyuki Otsuka1

  • 1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

JACC. Case Reports
|July 28, 2021
PubMed

Insights

This study presents a novel approach for managing recurrent in-stent restenosis (ISR) caused by calcified nodules, utilizing excimer laser catheter ablation to prevent further occurrences in a hemodialysis patient.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Nephrology

Background:

  • Recurrent in-stent restenosis (ISR) poses a significant challenge in interventional cardiology, particularly in patients with comorbidities like those on hemodialysis.
  • Neointimal hyperplasia is a common cause of ISR, but calcified nodules can also impede coronary blood flow post-intervention.

Keywords:
ACS, acute coronary syndromeCN, calcified noduleDAPT, dual-antiplatelet therapyDES, drug-eluting stentELCA, excimer laser catheter ablationISR, in-stent restenosisIVUS, intravascular ultrasoundOCT, optical coherence tomographyPCI, percutaneous coronary interventionRCA, right coronary arterycalcified nodulein-stent restenosisintravascular imagingpercutaneous coronary intervention

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