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Osimertinib-Induced Cardiomyopathy

Shruti R Patel1, Sherry-Ann N Brown2, Jilan E Kubusek3

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.

JACC. Case Reports
|July 28, 2021
PubMed

Insights

Osimertinib can cause acute heart failure in patients with metastatic non-small cell lung cancer. This cardiotoxicity appears reversible and linked to an 80 mg/day dose, suggesting careful monitoring during treatment.

Area of Science:

  • Oncology
  • Cardiology
  • Pharmacology

Background:

  • Osimertinib is a targeted therapy for metastatic non-small cell lung cancer (NSCLC) with specific epidermal growth factor receptor (EGFR) mutations.
  • Standard osimertinib dosage is 80 mg/day, and it is generally well-tolerated.

Observation:

  • A case series identified acute cardiomyopathy and heart failure exacerbation in patients undergoing osimertinib treatment.
  • These cardiac events manifested during therapy with osimertinib at the standard 80 mg/day dose.

Findings:

  • The observed cardiotoxicity associated with osimertinib treatment was reversible.
  • The cardiac adverse events were dose-dependent, specifically noted at 80 mg/day.

Implications:

  • Cardiotoxicity is a potential adverse effect of osimertinib that requires clinical awareness.
  • Monitoring cardiac function in patients receiving osimertinib may be warranted, especially at the standard 80 mg/day dose.
  • The reversibility of osimertinib-induced cardiotoxicity suggests potential for management and continued oncologic therapy.
Keywords:
CHF, congestive heart failureEF, ejection fractionEGFR, epidermal growth factor receptorNSCLC, non–small cell lung cancerTKI, tyrosine kinase inhibitorcardio-oncologycardiotoxicityheart failureosimertinibreduced ejection fraction

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