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Related Concept Videos

Anticholinesterase Agents: Poisoning and Treatment01:26

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Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
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Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
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Physical Properties of Amines01:26

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Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
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Agouti: A Lethal Allele
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Ferric Chloride-induced Murine Thrombosis Models
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Colchicine Toxicity: The Fatal Masquerader.

Vinaya Mulkareddy1, Carly Sokach2, Eric Bucklew2

  • 1Department of Cardiology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania.

JACC. Case Reports
|July 28, 2021
PubMed
Summary
This summary is machine-generated.

Colchicine toxicity can cause fatal multiorgan failure. A case study shows packed red blood cell exchange successfully treated transient biventricular failure and cardiogenic shock from colchicine toxicity.

Keywords:
CO, cardiac outputCRRT, continuous renal replacement therapyLVEF, left ventricular ejection fractionPAD, pulmonary artery diastolic pressurePRBC, packed red blood cellRBC, red blood cellSVRI, systemic vascular resistance indexedbiventricular failurecardiogenic shockcolchicine toxicitypacked red blood cell exchange

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Area of Science:

  • Cardiology
  • Toxicology
  • Hematology

Background:

  • Colchicine is a potent anti-inflammatory agent used for gout and other conditions.
  • Colchicine overdose can lead to severe toxicity, including multiorgan failure.
  • Cardiotoxicity is a rare but serious complication of colchicine toxicity.

Observation:

  • A patient presented with symptoms of severe colchicine toxicity.
  • The patient developed transient biventricular failure and cardiogenic shock.
  • Standard treatments for cardiogenic shock were initiated.

Findings:

  • Packed red blood cell exchange was performed as an unconventional treatment.
  • The patient's biventricular function and cardiogenic shock resolved following the procedure.
  • This intervention demonstrated a successful outcome in a critical care setting.

Implications:

  • Packed red blood cell exchange may be a viable therapeutic option for colchicine-induced cardiotoxicity.
  • This case highlights the importance of considering advanced hematologic interventions in severe toxicological emergencies.
  • Further research is warranted to explore the efficacy and mechanisms of red blood cell exchange in managing colchicine toxicity.