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Updated: Aug 4, 2026

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves
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Published on: August 23, 2011

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First-in-Man 4-Chamber Pressure-Volume Analysis During Transcatheter Aortic Valve Replacement for Bicuspid Aortic

Mohammad Sarraf1,2, Daniel Burkhoff3,4, Michael I Brener4

  • 1Division of Cardiology, Mayo Clinic, Rochester, Minnesota, USA.

JACC. Case Reports
|July 28, 2021
PubMed

Insights

Pressure-volume analysis reveals that transcatheter aortic valve replacement impacts each heart chamber differently. The entire procedure, including rapid pacing, influences these hemodynamic changes, not solely the valve itself.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Cardiac Physiology

Background:

  • Transcatheter aortic valve replacement (TAVR) is a common procedure for aortic stenosis.
  • Hemodynamic assessment is crucial for understanding cardiac function post-TAVR.
  • Previous studies have not fully detailed pressure-volume dynamics across all four chambers.

Observation:

  • This study presents the first human data on pressure-volume analysis in all four cardiac chambers before and after TAVR.
  • Detailed pressure-volume loops were acquired in the left ventricle, right ventricle, left atrium, and right atrium.
  • Hemodynamic parameters were measured during rapid ventricular pacing, a component of the TAVR procedure.

Findings:

  • Pressure-volume analysis demonstrated significant, chamber-specific hemodynamic alterations following TAVR.
  • The observed changes were influenced by the overall TAVR procedure, including rapid ventricular pacing, not exclusively by valve deployment.
  • Individual chamber responses varied, highlighting the complexity of post-TAVR hemodynamics.

Implications:

  • These findings provide novel insights into the acute hemodynamic effects of TAVR.
  • Understanding chamber-specific responses can help optimize TAVR procedural techniques.
  • This analysis may guide future strategies for managing patients undergoing TAVR and improve long-term outcomes.

Keywords:
AS, aortic stenosisLA, left atrial/atriumLV, left ventricle/ventricularPV, pressure–volumeRA, right atrial/atriumRV, right ventricle/ventricularRVP, rapid ventricular pacingTAVR, transcatheter aortic valve replacementaortic valvebicuspid aortic valvehemodynamicsleft ventricleright ventriclevalve replacement

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