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Updated: Oct 26, 2025

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Superior Mesenteric Artery Dissection: Classical Presentation, Novel Genetic Determinants
Ersilia M DeFilippis1, Martin Solomon1, Joseph Loscalzo1
1Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Superior mesenteric artery dissection, a rare cause of acute abdomen, can stem from various vascular conditions. Genetic testing may reveal underlying vasculopathy mechanisms in these cases.
Area of Science:
- Vascular Surgery
- Genetics
- Abdominal Imaging
Background:
- Superior mesenteric artery (SMA) dissection is an uncommon cause of acute abdominal pain.
- Etiologies include atherosclerosis, medial degeneration, aneurysms, hypertension, and arteriopathies.
Observation:
- This case report details a patient presenting with SMA dissection.
- Clinical genetic testing was pursued to explore the root causes of the arterial disease.
Findings:
- The investigation aimed to identify potential genetic predispositions or underlying mechanisms contributing to the dissection.
- Genetic analysis can offer insights into rare vasculopathies.
Implications:
- Understanding the genetic basis of SMA dissection can improve diagnostic approaches.
- This case highlights the utility of genetic testing in elucidating rare vascular conditions.
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