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Updated: Oct 26, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
A Cautionary Tale of Triple Therapy
Negeen Shahandeh1, Jeffrey Harrell1, Eric H Yang1
1Division of Cardiology, University of California-Los Angeles, Los Angeles, California, USA.
Abstract:
A 54-year-old man with a history of atrial flutter presented with anterior ST-segment elevation myocardial infarction complicated by cardiogenic shock and underwent percutaneous coronary intervention of the left main coronary artery. He was placed on triple antithrombotic therapy and ultimately recovered. However, before discharge, he developed hypotension, confusion, and hemiplegia. (Level of Difficulty: Beginner.).
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