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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Updated: Oct 26, 2025

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
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A 30-Year-Old Man With Primary Cardiac Angiosarcoma.

Nicholas Jex1, Jonathan Farley2, Sharmaine Thirunavukarasu1

  • 1University of Leeds, Multidisciplinary Cardiovascular Research Centre and Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, United Kingdom.

JACC. Case Reports
|July 28, 2021
PubMed
Summary

A rare primary cardiac angiosarcoma was diagnosed in a young man presenting with chest pain and fever. Multimodality imaging and histopathology confirmed the diagnosis, guiding clinical management.

Keywords:
CMR, cardiovascular magnetic resonance imagingRA, right atrialRCA, right coronary arteryRV, right ventriclecardiac angiosarcomacardiac magnetic resonanceechocardiographyimagingmalignancypositron emission tomography

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Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Primary cardiac tumors are rare, with angiosarcoma being an aggressive subtype.
  • Early diagnosis is crucial for effective management of cardiac angiosarcoma.

Observation:

  • A 30-year-old male presented with palpitations, fever, and pleuritic chest pain.
  • Symptoms suggested an underlying cardiac or pulmonary pathology.

Findings:

  • Multimodality imaging, including echocardiography, MRI, and CT, revealed a cardiac mass.
  • Histopathological examination confirmed the diagnosis of primary cardiac angiosarcoma.

Implications:

  • This case highlights the importance of considering rare diagnoses in young, otherwise healthy individuals.
  • Multimodality imaging plays a vital role in the diagnostic process of cardiac tumors.
  • Timely diagnosis and tailored management are essential for improving outcomes in primary cardiac angiosarcoma.