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Mogamulizumab-Associated Acute Myocarditis in a Patient With T-Cell Lymphoma

Jennifer M Kwan1, Natalija Odanovic1, Amit Arbune1

  • 1Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

JACC. Case Reports
|July 28, 2021
PubMed

A 62-year-old woman with human T-lymphotropic virus type 1 cell lymphoma developed heart failure after mogamulizumab, an immunotherapy agent. Clinical presentation and cardiac magnetic resonance imaging were consistent with myocarditis, and a recurrence of heart failure occurred after rechallenge with the therapy. (Level of Difficulty: Advanced.).

Keywords:
CCR4, C-X-C chemokine receptor type 4CHOPE, cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposideCMR, cardiac magnetic resonanceECG, electrocardiogramICI, checkpoint inhibitorLGE, late gadolinium enhancementLVEF, left ventricular ejection fractionMR sequencesPE, pulmonary embolusTTE, transthoracic echocardiogramTreg, T regulatory cellsacute heart failurecancercardiomyopathy

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