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Updated: Oct 26, 2025
Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
Published on: August 7, 2018
[Research progress of necroptosis on bone related diseases]
Zu-Ge Yang1, Ruo-Xin Wang1, Hao-Zhe Ren1
1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
Abstract:
As a new type of cell death, necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1), and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3), following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal. When necroptosis happens, damage associated molecular patterns (DAMPs) enter into extracellular area through the ruptured cytomembrane, followed by the disordered tissue hemeostasis. In recent years, many researches showed that necroptosis playimportant roles in a few bone related diseases, such as osteoporosis, osteonecrosis, osteosarcoma, etc. Thus, we try to briefly review the researches in this field.
Insights
Necroptosis, a programmed cell death pathway, is involved in bone diseases like osteoporosis and osteosarcoma. This review summarizes current research on necroptosis
Area of Science:
- Cellular Biology
- Pathology
- Biochemistry
Background:
- Necroptosis is a regulated form of necrosis initiated by specific signaling pathways.
- This cell death mechanism involves key proteins like RIPK1, RIPK3, and MLKL.
- Necroptosis triggers the release of damage-associated molecular patterns (DAMPs), disrupting tissue homeostasis.
Purpose of the Study:
- To review the current research on the role of necroptosis in bone-related diseases.
- To highlight the involvement of necroptosis in conditions such as osteoporosis, osteonecrosis, and osteosarcoma.
Main Methods:
- Literature review of recent studies on necroptosis and bone diseases.
- Analysis of signaling pathways involved in necroptosis.
- Examination of the impact of necroptosis on bone tissue homeostasis.
Main Results:
- Necroptosis plays a significant role in the pathogenesis of several bone diseases.
- The dysregulation of necroptosis contributes to conditions like osteoporosis and osteonecrosis.
- Necroptosis is implicated in the development and progression of osteosarcoma.
Conclusions:
- Necroptosis is an emerging area of research with implications for bone disease treatment.
- Understanding necroptosis pathways may offer novel therapeutic targets for bone-related pathologies.
- Further research is needed to fully elucidate the role of necroptosis in bone health and disease.
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