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Updated: Jun 28, 2026
14:43
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
12.2K
Original Article: Clinical Research
Gulay Dasdemir Ilkhan1, Fatma Demirci Üçsular2, Hakan Celikhisar3
1Department of Chest Diseases, Tire State Hospital, Izmir-Turkey.
Summary
Serum endotrophin levels are elevated in patients with fibrotic interstitial lung diseases (ILD). This finding suggests endotrophin may serve as a diagnostic marker for fibrotic ILD.
Area of Science:
- Pulmonology
- Biochemistry
- Pathology
Background:
- Interstitial lung diseases (ILD) encompass a range of conditions.
- Pulmonary fibrosis is a severe manifestation of ILD.
- Endotrophin, a collagen VI byproduct, is implicated in fibrosis.
Purpose of the Study:
- To investigate the role of endotrophin in pulmonary fibrosis within ILD.
- To assess serum endotrophin levels in patients with and without fibrotic ILD.
Main Methods:
- Study included 35 fibrotic ILD patients, 35 non-fibrotic ILD patients, and 20 controls.
- Pulmonary function tests (spirometry, DLCO) and blood markers (CRP, LDH) were analyzed.
- Serum endotrophin levels were quantified in all participants.
Main Results:
- Fibrotic ILD patients showed significantly higher serum endotrophin levels than non-fibrotic ILD patients and controls.
- Endotrophin levels did not differ significantly between non-fibrotic ILD patients and controls.
- Smoking history and reduced diffusion capacity (DLCO, KCO) correlated with higher endotrophin levels.
Conclusions:
- Serum endotrophin is significantly elevated in fibrotic ILD.
- Endotrophin shows potential as a diagnostic biomarker for fibrotic interstitial lung diseases.
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