Highly sensitive non-enzymatic electrochemical glucose sensor surpassing water oxidation interference

Area of Science:

• Electrochemistry
• Materials Science
• Biosensors

Background:

• Enzyme-based glucose sensors face limitations like instability and interference.
• Development of non-enzymatic glucose sensors is crucial for reliable glucose monitoring.

Purpose of the Study:

• To develop a highly sensitive and selective electrochemical non-enzymatic sensor for glucose determination.
• To investigate the performance of a novel NiVP/Pi material for glucose sensing.
• To create a flexible sensor for practical glucose monitoring applications.

Main Methods:

• Fabrication of a NiVP/Pi material-based electrochemical sensor.
• Electrochemical characterization of the sensor's performance, including sensitivity, selectivity, and detection limit.
• Development of a flexible sensor by immobilizing NiVP/Pi on filter paper.
• Testing the sensor's performance with human blood serum samples.

Main Results:

• The NiVP/Pi sensor exhibited high sensitivity (6.04 mA μM⁻¹ cm⁻²) and a low detection limit (3.7 nM) for glucose.
• The sensor demonstrated excellent selectivity, with no interference from common interferents or the oxygen evolution reaction.
• A flexible version of the sensor showed two linear ranges with ultra-sensitivity.
• The sensor performed effectively in detecting glucose in human blood serum samples.

Conclusions:

• The developed NiVP/Pi-based electrochemical sensor provides a sensitive, selective, and stable platform for non-enzymatic glucose detection.
• The flexible sensor design offers a convenient and practical approach for glucose monitoring.
• Fine-tuning the NiVP/Pi composition presents a promising strategy for advancing electrochemical glucose sensing technology.