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Association between atopic dermatitis and hypertension: a systematic review and meta-analysis
M Yousaf1, M Ayasse2, A Ahmed1
1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
The British Journal of Dermatology
|July 28, 2021
Summary
Atopic dermatitis (AD) is linked to a higher risk of hypertension, especially in moderate-to-severe cases. However, the odds of hypertension are lower in AD patients compared to those with psoriasis.
Area of Science:
- Dermatology
- Cardiology
- Epidemiology
Background:
- Conflicting evidence exists regarding the association between atopic dermatitis (AD) and hypertension.
- Previous studies have yielded inconsistent results on this relationship.
Purpose of the Study:
- To investigate the association between atopic dermatitis (AD) and hypertension.
- To determine if AD severity correlates with hypertension risk.
Main Methods:
- A systematic review and meta-analysis of published studies.
- Searched major databases including Ovid MEDLINE, Embase, Scopus, Web of Science, and GREAT.
- Assessed study quality using the Newcastle-Ottawa Scale.
Main Results:
- Fifty-one studies were included; 19 underwent meta-analysis.
- Atopic dermatitis (AD) was associated with increased odds of hypertension versus healthy controls (OR 1.16).
- Moderate-to-severe AD showed a significantly higher association with hypertension (OR 2.33).
- AD patients had lower odds of hypertension compared to psoriasis patients (OR 0.53).
- Hypertension was a noted adverse event of AD treatments, especially ciclosporin A.
Conclusions:
- Atopic dermatitis (AD), particularly moderate-to-severe forms, is associated with an increased risk of hypertension.
- The hypertension risk in AD is elevated compared to healthy individuals but lower than in psoriasis.
- Further research is needed due to limitations like lack of longitudinal data.
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