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Time-temperature indicators versus temperature indicators for transfusion practice: Application in the real hospital
Mikyoung Park1, Mina Hur2, Hanah Kim2
1Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, South Korea.
Vox Sanguinis
|July 28, 2021
Summary
The Freshzone time-temperature indicator (TTI) shows longer temperature excursions than standard indicators for red blood cell units. This new TTI is a viable option for improving transfusion safety.
Area of Science:
- Biomedical Engineering
- Transfusion Medicine
- Medical Device Technology
Background:
- Temperature indicators (TIs) are crucial for monitoring red blood cell (RBC) unit surface temperatures.
- Existing TIs include Safe-T-Vue 10 (STV10) and Blood Temp 10 (BT10).
- A new time-temperature indicator prototype, Freshzone TTI (FZTTI), was developed.
Purpose of the Study:
- To compare the utility of the FZTTI prototype against two FDA-approved TIs (STV10 and BT10).
- To evaluate the performance of these indicators in monitoring RBC unit temperatures post-issue.
Main Methods:
- 91 RBC units were monitored using FZTTI, STV10, and BT10 after issue.
- Eight units were specifically monitored after storage in ward refrigerators.
- Color change (CC) times were recorded, indicating temperature excursions above 10°C, with a 30-minute rule applied.
Main Results:
- Median CC times significantly differed: FZTTI (51.4 min) vs. STV10 (13.9 min) and BT10 (10.5 min) (p < 0.001).
- FZTTI showed CC after 30 min in 95.2% of units, while STV10 and BT10 did so in 96.4% and 98.8%, respectively.
- Significant differences in CC times were observed for RBC units stored in refrigerators.
Conclusions:
- The FZTTI demonstrated superior performance compared to STV10 and BT10.
- FZTTI is a feasible and potentially improved option for monitoring RBC unit temperatures in transfusion practice.
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