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Physical Exercise Training and Chagas Disease: Potential Role of MicroRNAs

Alex Cleber Improta-Caria1,2, Roque Aras Júnior1

  • 1Programa de Pós-Graduação em Medicina e Saúde, Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA - Brasil.

Arquivos Brasileiros De Cardiologia
|July 28, 2021
PubMed

Insights

This review explores microRNAs (miRNAs) in Chagas disease (CD) and how physical exercise training (PET) might alter them. Understanding these molecular changes could reveal new therapeutic targets for Chronic Chagas Cardiomyopathy (CCC).

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Parasitology

Background:

  • Chagas disease (CD), caused by Trypanosoma Cruzi, leads to Chronic Chagas Cardiomyopathy (CCC) through cardiac inflammation and remodeling.
  • The molecular mechanisms underlying CD pathogenesis, particularly the role of microRNAs (miRNAs), remain poorly understood.
  • miRNAs are key post-transcriptional gene regulators involved in various pathophysiological processes.

Purpose of the Study:

  • To identify specific miRNAs implicated in Chagas disease.
  • To explore the potential of physical exercise training (PET) to modulate miRNA expression in CD.
  • To bridge the knowledge gap regarding the interplay between PET, miRNAs, and CD.

Main Methods:

  • Literature review synthesizing existing evidence on miRNAs in Chagas disease.
  • Analysis of studies investigating the effects of physical exercise training on miRNA expression in general.
  • Identification of potential miRNA targets for therapeutic intervention in CD.

Main Results:

  • Limited understanding exists regarding the specific miRNAs involved in Chagas disease pathophysiology.
  • Physical exercise training (PET) is known to modulate miRNA expression in healthy individuals.
  • Evidence linking PET to miRNA modulation specifically in Chagas disease patients is currently absent.

Conclusions:

  • Further research is needed to elucidate the role of specific miRNAs in Chagas disease.
  • Physical exercise training (PET) presents a potential non-pharmacological strategy to modulate disease-related miRNAs.
  • Identifying miRNAs modulated by PET could pave the way for novel therapeutic approaches for Chronic Chagas Cardiomyopathy (CCC).

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