Related Experiment Video

Updated: Oct 26, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.6K

Analyzing the impact of CFP1 mutational landscape on epigenetic signaling

Yidai Yang1,2,3, Yaqing Yang1,3, Kin Chan1,3

  • 1Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 28, 2021
PubMed

Insights

CXXC Zinc finger protein 1 (CFP1) impacts epigenetic events like DNA methylation and histone modification. This review explores CFP1

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • CXXC Zinc finger protein 1 (CFP1) is a key regulator in cellular processes.
  • CFP1's interactions influence numerous epigenetic mechanisms.
  • Understanding CFP1 is crucial for developmental biology and disease.

Purpose of the Study:

  • To review the diverse functions of CFP1.
  • To elucidate CFP1's role in DNA methylation and histone modifications.
  • To discuss CFP1's involvement in cancer and the implications of its mutations.

Main Methods:

  • Literature review of CFP1's functions.
  • Analysis of CFP1's impact on epigenetic modifications.
  • Discussion of CFP1's role in carcinogenesis based on existing studies.

Main Results:

  • CFP1 is integral to epigenetic regulation, affecting DNA methylation.
  • CFP1 influences post-translational modifications of histones, including acetylation and methylation.
  • Mutations in CFP1 are linked to various cancers, suggesting a role in oncogenesis.

Conclusions:

  • CFP1 is a critical protein with multifaceted roles in epigenetics and development.
  • CFP1's dysregulation is implicated in cancer development.
  • Further research into CFP1 mutations may offer therapeutic insights.
Keywords:
CFP1cancerepigenetics

More Related Videos

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.8K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.6K

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.7K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.7K
Mutations01:39

Mutations

Overview
86.2K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.3K