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Native starch in tablet formulations: properties on compaction.

C E Bos1, G K Bolhuis, H Van Doorne

  • 1Laboratory for Pharmaceutical Technology and Dispensing, State University of Groningen, The Netherlands.

Pharmaceutisch Weekblad. Scientific Edition
|October 16, 1987
PubMed
Summary
This summary is machine-generated.

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Rice starch demonstrates superior compactibility and lubricant insensitivity for direct compression tablets compared to maize, potato, and tapioca starch. Granulation enhances rice starch

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Starches are widely used as excipients in pharmaceutical formulations.
  • Understanding starch properties is crucial for optimizing tablet manufacturing processes.

Purpose of the Study:

  • To evaluate and compare the direct compression properties of maize, potato, rice, and tapioca (cassava) starches.
  • To assess the impact of magnesium stearate and moisture content on starch compactibility and tablet strength.

Main Methods:

  • Direct compression evaluation of four different starches.
  • Assessment of compactibility, binding capacity, and lubricant sensitivity.
  • Analysis of the effect of equilibrium moisture content on powder properties.
  • Investigation of granulation effects on rice starch.

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Main Results:

  • Rice starch exhibited significantly better compactibility and binder stability with magnesium stearate compared to other starches.
  • Tablet strength was influenced by the equilibrium moisture content, which depends on relative humidity.
  • All starches possessed adequate water uptake for disintegration.
  • Rice starch had poor flowability due to fine particle size, but granulation improved its suitability as a filler-binder.

Conclusions:

  • Rice starch is a promising candidate for direct compression tablet formulations, offering superior compactibility and lubricant tolerance.
  • Moisture content is a critical factor affecting starch compactibility.
  • Granulation is an effective method to improve the processing characteristics of rice starch for direct compression.