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Related Experiment Video

Updated: Oct 26, 2025

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Sepsis and multiple sclerosis: Causative links and outcomes.

Đorđe Miljković1, Suzana Stanisavljević1, Isaac J Jensen2

  • 1Department of Immunology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.

Immunology Letters
|July 28, 2021
PubMed
Summary

Sepsis survivors experience immune dysfunction, increasing infection risk. This review explores the complex, two-way link between sepsis and multiple sclerosis, focusing on immune mechanisms.

Keywords:
Gut microbiotaMultiple sclerosisSepsis

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Related Experiment Videos

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Area of Science:

  • Immunology
  • Neurology
  • Infectious Diseases

Background:

  • Sepsis triggers acute inflammation and prolonged immune suppression.
  • Post-septic immune deficits heighten vulnerability to secondary infections and late mortality.
  • This immune paralysis may impact autoimmune diseases like multiple sclerosis (MS).

Purpose of the Study:

  • To review the bidirectional relationship between sepsis and multiple sclerosis.
  • To elucidate the immunological mechanisms underlying this interaction.
  • To identify future research directions.

Main Methods:

  • Literature review of studies on sepsis and multiple sclerosis.
  • Analysis of immunological pathways connecting sepsis and autoimmunity.
  • Synthesis of current evidence on the interplay between these conditions.

Main Results:

  • Sepsis can exacerbate or trigger autoimmune processes.
  • Autoimmune conditions may influence sepsis susceptibility and severity.
  • Shared immune dysregulation underlies the sepsis-MS connection.

Conclusions:

  • The interaction between sepsis and multiple sclerosis is complex and bidirectional.
  • Understanding these immunologic links is crucial for patient outcomes.
  • Further research is needed to explore therapeutic strategies.