Immunosuppression of mice by delta-9-tetrahydrocannabinol

Studies were initiated to determine the effects of delta-9-tetrahydrocannibinol (THC) on the production of indirect IgG plaque-forming and rosette-forming cells in mice. BDF1 mice were immunized with sheep erythrocytes followed by multiple injections of 10, 25 or 40 mg/kg THC. Results indicated that both parameters were significantly reduced by 25 mg/kg, thus affirming the immunosuppressive properties of this substance in mice.