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Valvular Calcific Deposits and Mortality in Peritoneal Dialysis Patients: A Propensity Score-Matched Cohort Analysis

Aiwen Shen1, Linsen Jiang2, Yunhuan Tian3

  • 1Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China, shenaiwensaw@163.com.

Cardiorenal Medicine
|July 28, 2021
PubMed

Insights

Cardiac valve calcification (CVC) is an independent risk factor for mortality in peritoneal dialysis (PD) patients. This study found CVC significantly increases mortality risk in PD patients, highlighting the need for closer monitoring.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular complications are a leading cause of mortality in patients undergoing peritoneal dialysis (PD).
  • Cardiac valve calcification (CVC) is a common comorbidity in end-stage renal disease patients, but its impact on PD patient outcomes is not fully understood.

Purpose of the Study:

  • To investigate the association between cardiac valve calcification (CVC) and all-cause mortality in patients undergoing peritoneal dialysis (PD).
  • To identify CVC as an independent risk factor for mortality in the PD population.

Main Methods:

  • A retrospective cohort study included 310 PD patients (2009-2016) with follow-up until 2018.
  • Patients were categorized into groups with and without CVC (including aortic valve calcification and mitral valve calcification).
  • A Fine-Gray proportional hazards model was used to analyze mortality differences after propensity score matching.

Main Results:

  • Of 310 patients, 73 had CVC. After matching, 68 pairs were analyzed.
  • Age and CVC were identified as independent risk factors for mortality.
  • The CVC group showed a significantly higher mortality risk (HR: 1.83, p < 0.05).

Conclusions:

  • Cardiac valve calcification (CVC) is an independent risk factor associated with increased mortality in peritoneal dialysis (PD) patients.
  • These findings underscore the importance of assessing and managing CVC in PD patients to improve survival outcomes.
Abstract

Keywords:
Cardiac valve calcificationCardiovascular riskMortalityPeritoneal dialysisPropensity score

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