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Updated: Oct 26, 2025

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
Small cell neuroendocrine carcinoma disguised as an external hemorrhoid
Amelia Allmark1, Mary L Brubaker
1At the time this article was written, Amelia Allmark was a student in the PA program at Northern Arizona University in Phoenix. She now practices in oncology/hematology with Utah Cancer Specialists at the Jordan Valley Hospital in West Jordan, Utah. Mary L. Brubaker is an associate clinical professor in the PA program at Northern Arizona University. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
This article describes a patient who presented to the ED with persistent nausea and vomiting, constipation, weight loss, and a new complaint of an external hemorrhoid and hematochezia with stooling. Comprehensive diagnostic evaluation included imaging studies that showed extensive metastatic disease but did not identify a primary neoplasm. Biopsy of the external hemorrhoid revealed small cell neuroendocrine carcinoma of the anal canal.
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