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Association between serum uric acid level and mortality in China
Dong-Yuan Chang1,2,3,4, Jin-Wei Wang1,2,3,4, Min Chen1,2,3,4
1Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing 100034, China.
Chinese Medical Journal
|July 28, 2021
Summary
Serum uric acid (SUA) levels show a U-shaped association with mortality risk in Chinese men, but not in women. This finding highlights sex-specific differences in SUA
Area of Science:
- Epidemiology
- Public Health
- Biochemistry
Background:
- The relationship between serum uric acid (SUA) levels and mortality risk in the general population is not well-established.
- Previous studies have yielded inconclusive results regarding SUA's impact on mortality.
Purpose of the Study:
- To investigate the association between serum uric acid (SUA) levels and all-cause, cardiovascular disease (CVD), and cancer mortality in the Chinese population.
- To determine if this association differs between sexes.
Main Methods:
- A population-based cohort study utilizing data from the China National Survey of Chronic Kidney Disease linked to mortality data.
- Analysis included 33,268 participants with complete SUA data, followed from 2006 to 2017.
- Cox proportional hazards regression models were employed to assess the effect of SUA levels on mortality rates.
Main Results:
- A U-shaped association between SUA levels and all-cause and CVD mortality was observed exclusively in men.
- For men, elevated SUA levels in the lowest and highest quartiles were associated with increased all-cause and CVD mortality compared to the third quartile.
- No significant associations between SUA levels and mortality were detected in women.
Conclusions:
- The association between serum uric acid (SUA) and mortality risk is sex-dependent.
- A U-shaped relationship exists between SUA levels and both all-cause and cardiovascular disease mortality in Chinese men.
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