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General Transcription Factors

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

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Related Experiment Video

Updated: Oct 26, 2025

Author Spotlight: Deciphering the Cellular Mysteries of Intermuscular Adipose Tissue in Humans

Author Spotlight: Deciphering the Cellular Mysteries of Intermuscular Adipose Tissue in Humans

Published on: May 3, 2024

A single-cell type transcriptomics map of human tissues.

Max Karlsson¹, Cheng Zhang¹, Loren Méar²

¹Science for Life Laboratory, Department of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden.

Science Advances

|July 29, 2021

Summary

This summary is machine-generated.

Researchers created a high-resolution human tissue map using single-cell transcriptomics and protein profiling. This open-access atlas reveals gene expression across 192 cell types, aiding functional comparisons.

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Last Updated: Oct 26, 2025

Author Spotlight: Deciphering the Cellular Mysteries of Intermuscular Adipose Tissue in Humans

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Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

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Published on: March 14, 2022

Area of Science:

Molecular Biology
Genomics
Human Anatomy

Background:

Molecular profiling technologies enable gene expression mapping in human cells, tissues, and organs.
Understanding cell-specific gene expression is crucial for deciphering tissue function and disease mechanisms.

Purpose of the Study:

To develop a high-resolution single-cell type map of human tissues.
To integrate single-cell transcriptomics with spatial protein profiling for comprehensive analysis.
To create an open-access resource for exploring human gene expression patterns.

Main Methods:

Combined single-cell transcriptomics with spatial antibody-based protein profiling.
Analyzed gene expression across 192 distinct cell type clusters.
Classified gene expression specificity for each cell type and compared with bulk transcriptomics data.

Main Results:

Generated a high-resolution single-cell type map of human tissues.
Launched an open-access atlas detailing human protein-coding gene expression.
Identified distinct expression clusters correlating with cell types sharing similar functions across and within organs.

Conclusions:

The integrated approach provides unprecedented resolution of human tissue cellular composition and gene expression.
The open-access atlas facilitates research into cell-type-specific gene function and tissue organization.
Expression patterns reveal functional similarities among cell types, offering insights into conserved biological processes.