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Updated: Oct 26, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Multiorgan thrombosis as a complication of COVID-19 pneumonia
Etienne Ceci Bonello1, Ramon Casha2, Thelma Xerri2
1General Medicine, Mater Dei Hospital, Msida, Malta etienne.ceci@gov.mt.
Abstract:
A 47-year-old man, positive for SARS-CoV-2, was diagnosed with acute coronary syndrome (ACS) complicated by myocarditis on a background of COVID-19 pneumonia. He was medically treated for ACS; however, 3 days into his admission, the patient developed neurological complications confirmed on MRI of the brain. MRI showed established infarcts involving a large part of the left temporal lobe and right occipital lobe, with minor foci of micro-haemorrhagic transformation in the left temporal lobe. A left ventricular mural thrombus was then confirmed on echocardiogram, and this was attributed as the cause of his neurological infarct. Further infarctions in the kidneys and spleen, and thrombi in the superior mesenteric and left femoral artery were also identified on imaging of the abdomen. The left ventricular mural thrombus was removed surgically via a midline sternotomy incision under general anaesthesia. Surgery was successful and the patient was discharged to a rehabilitation centre.
Insights
A COVID-19 patient developed severe cardiac and neurological complications, including a left ventricular mural thrombus causing multiple infarcts. Surgical removal of the thrombus was successful, leading to patient recovery and discharge.
Area of Science:
- Cardiology
- Neurology
- Infectious Diseases
Background:
- COVID-19 pneumonia can lead to severe systemic complications.
- Acute coronary syndrome (ACS) and myocarditis are potential cardiac manifestations of SARS-CoV-2 infection.
Observation:
- A 47-year-old male with COVID-19 pneumonia developed ACS and myocarditis.
- Neurological complications, including large temporal and occipital lobe infarcts, were confirmed via brain MRI.
- Echocardiogram revealed a left ventricular mural thrombus, identified as the cause of neurological infarcts.
Findings:
- The patient experienced multiple organ infarctions (brain, kidneys, spleen) and arterial thromboses (superior mesenteric, left femoral).
- Surgical excision of the left ventricular mural thrombus was performed successfully under general anesthesia.
- Post-surgery, the patient demonstrated recovery and was discharged to a rehabilitation facility.
Implications:
- This case highlights the potential for SARS-CoV-2 to cause extensive thromboembolic events beyond the lungs.
- Left ventricular mural thrombus formation is a critical complication of severe COVID-19, necessitating prompt diagnosis and management.
- Multidisciplinary management involving cardiology, neurology, and cardiothoracic surgery is crucial for patients with complex COVID-19-related thromboembolic complications.
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