Multiorgan thrombosis as a complication of COVID-19 pneumonia

Etienne Ceci Bonello1, Ramon Casha2, Thelma Xerri2

  • 1General Medicine, Mater Dei Hospital, Msida, Malta etienne.ceci@gov.mt.

BMJ Case Reports
|July 29, 2021
PubMed

Insights

A COVID-19 patient developed severe cardiac and neurological complications, including a left ventricular mural thrombus causing multiple infarcts. Surgical removal of the thrombus was successful, leading to patient recovery and discharge.

Area of Science:

  • Cardiology
  • Neurology
  • Infectious Diseases

Background:

  • COVID-19 pneumonia can lead to severe systemic complications.
  • Acute coronary syndrome (ACS) and myocarditis are potential cardiac manifestations of SARS-CoV-2 infection.

Observation:

  • A 47-year-old male with COVID-19 pneumonia developed ACS and myocarditis.
  • Neurological complications, including large temporal and occipital lobe infarcts, were confirmed via brain MRI.
  • Echocardiogram revealed a left ventricular mural thrombus, identified as the cause of neurological infarcts.

Findings:

  • The patient experienced multiple organ infarctions (brain, kidneys, spleen) and arterial thromboses (superior mesenteric, left femoral).
  • Surgical excision of the left ventricular mural thrombus was performed successfully under general anesthesia.
  • Post-surgery, the patient demonstrated recovery and was discharged to a rehabilitation facility.

Implications:

  • This case highlights the potential for SARS-CoV-2 to cause extensive thromboembolic events beyond the lungs.
  • Left ventricular mural thrombus formation is a critical complication of severe COVID-19, necessitating prompt diagnosis and management.
  • Multidisciplinary management involving cardiology, neurology, and cardiothoracic surgery is crucial for patients with complex COVID-19-related thromboembolic complications.

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
534
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
76
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
200
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
92
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
1.2K
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
83