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Centrally administered bombesin modulates gastric motility
1Department of Neurology, Veterans Administration Medical Center, Iowa City, IA 52242.
Peptides
|September 1, 1987
Summary
Bombesin injected into the brainstem nucleus tractus solitarius (NTS) increases gastric pressure but not arterial pressure in rats. This effect, mediated centrally, highlights bombesin
Area of Science:
- Neuroscience
- Gastroenterology
- Physiology
Background:
- Bombesin is known to influence physiological functions.
- Its specific role in central regulation of gastric motility requires further investigation.
Purpose of the Study:
- To investigate the effects of bombesin microinjected into the medial nucleus tractus solitarius (mNTS) on arterial and gastric intraluminal pressure.
- To determine if bombesin acts centrally or peripherally to modulate gastric pressure.
Main Methods:
- Microinjection of bombesin into the mNTS of anesthetized rats.
- Measurement of arterial and gastric intraluminal pressures.
- Transection of the spinal cord and vagus nerves to differentiate central and peripheral effects.
Main Results:
- Central bombesin administration increased tonic and phasic gastric intraluminal pressure in a dose-dependent manner.
- Arterial pressure was not significantly altered by central bombesin.
- Intravenous bombesin increased tonic gastric pressure but not phasic pressure.
- Central effects were blocked by spinal cord and vagus nerve transection.
Conclusions:
- Bombesin microinjected into the mNTS modulates gastric motility by increasing gastric intraluminal pressures.
- Bombesin acts centrally within the NTS to influence gastric pressure.
- Bombesin may serve as a central regulator of gastric motility.