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Effect of multiple doses of clonazepam on the nitroreductase activity in hepatic microsomal preparation from rat
D Cenajek-Musiaø1, K Szczawińska, E Nowakowska
1Medical Academy, Department of Pharmacology, Poznań, Poland.
Polish Journal of Pharmacology and Pharmacy
|March 1, 1987
Abstract:
The hepatic microsomal nitroreductase activity and urinary excretion of the sum of the main metabolites of clonazepam (CNZ) were investigated in rats that had received 7 daily injections of 2 mg/kg of the compound. Despite the significant decrease in CNZ nitroreductase activity, there was only poor correlation between the enzyme activity and excretion of the assayed metabolites.