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Association Between Low-Dose Aspirin and Uric Acid in the Elderly: An Observational Retrospective Cross-Sectional

Jia-Run Li1, Yan Fan1, Mei-Lin Liu1

  • 1Department of Geriatrics, Peking University First Hospital, Beijing, 100034, People's Republic of China.

International Journal of General Medicine
|July 29, 2021
PubMed

Insights

Low-dose aspirin (50-100mg) for over a month did not significantly alter serum uric acid (SUA) or its urinary excretion in elderly patients. A slight decreasing trend in SUA was noted in those with hyperuricemia, but results were not statistically significant.

Area of Science:

  • Geriatrics
  • Cardiovascular Medicine
  • Nephrology

Background:

  • Uric acid is a risk factor for arteriosclerotic cardiovascular disease (ASCVD).
  • Low-dose aspirin is commonly used in ASCVD patients, but its effect on uric acid metabolism remains unclear.
  • Previous studies on aspirin's impact on uric acid have yielded controversial results.

Purpose of the Study:

  • To investigate the association between long-term low-dose aspirin use (≥1 month) and serum uric acid (SUA) levels.
  • To examine the effect of low-dose aspirin on urinary uric acid excretion in elderly patients.
  • To explore potential dose-dependent effects of aspirin (50-100mg/day) on uric acid metabolism.

Main Methods:

  • Observational, retrospective, cross-sectional study design.
  • Inclusion of 506 elderly inpatients (≥60 years) from a Geriatrics department.
  • Analysis of serum uric acid (SUA) and fractional excretion of uric acid (FEUA) in relation to aspirin use (≥1 month vs. none, and 50mg vs. 100mg daily doses).

Main Results:

  • No significant correlation was found between low-dose aspirin use and SUA or FEUA after adjusting for confounders.
  • A non-significant decreasing trend in SUA was observed in hyperuricemia patients taking low-dose aspirin (P=0.534).
  • No significant differences in SUA or FEUA were observed between patients taking 50mg/day versus 100mg/day of aspirin.

Conclusions:

  • Long-term use of low-dose aspirin (50-100mg/day) does not appear to significantly affect serum uric acid levels or urinary uric acid excretion in elderly patients.
  • The study did not find a significant association between aspirin use and altered uric acid metabolism in this population.
  • Further research may be needed to clarify the subtle effects in specific subgroups like those with hyperuricemia.
Abstract

Keywords:
arteriosclerotic cardiovascular diseaseaspirinelderlyexcretionuric acid

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