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Updated: Oct 26, 2025

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
Use of alternative cerebrospinal fluid-based biomarkers to help diagnose Xpert-negative tuberculous meningitis: A
Deechit Poudel1, Diptee Poudel2, Dhiraj Poudel2
1Nepalese Army Institute of Health Sciences-College of Medicine Kathmandu Nepal.
Abstract:
The widely used Xpert MTB/RIF assay, limited by its suboptimal sensitivity, does not perform well as a rule-out test for tuberculous meningitis. Alternative CSF-based biomarkers can help determine the microbial etiology of clinical meningitis when standard diagnostic modalities fail.
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