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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Carrier-Mediated Transport01:06

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Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
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Updated: Oct 26, 2025

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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[Research Development in Transfersome-Based Drug Delivery System].

Yi Liang1, Zhi-Rong Zhang1

  • 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|July 29, 2021
PubMed
Summary

Transfersomes, novel lipoid carriers, offer excellent drug delivery properties but require formulation optimization for systemic administration. Their deformability shows promise for crossing physiological barriers and developing transdermal vaccines.

Keywords:
DeformabilityFormulation processOral administrationSurfactantTransdermal administrationTransfersomes

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Area of Science:

  • * Pharmaceutical Sciences
  • * Nanotechnology
  • * Drug Delivery Systems

Background:

  • * Transfersomes are advanced lipoid carriers with unique properties like deformability and amphiphilicity.
  • * They are established for percutaneous and oral drug delivery.
  • * Formulation challenges impact their stability and efficacy for systemic administration routes.

Purpose of the Study:

  • * To review the properties, formulation, evaluation, and administration of transfersomes.
  • * To explore their potential in overcoming physiological barriers and in vaccine development.
  • * To analyze current research and future prospects for transfersome technology.

Main Methods:

  • * Comprehensive literature review on transfersomes.
  • * Analysis of formulation factors influencing transfersome characteristics.
  • * Examination of evaluation techniques and administration routes.
  • * Case studies and assessment of research achievements.

Main Results:

  • * Transfersomes exhibit deformability, pressure permeability, and amphiphilicity, beneficial for drug delivery.
  • * Formulation significantly impacts stability and effectiveness, especially for intravenous use.
  • * Potential demonstrated for penetrating the blood-brain barrier and in transdermal vaccine research.

Conclusions:

  • * Transfersome formulation requires careful optimization for enhanced stability and efficacy across various administration routes.
  • * Their unique properties present significant opportunities for targeted drug delivery and novel vaccine development.
  • * Further research is warranted to fully harness the potential of transfersomes in advanced therapeutics.