Related Experiment Video
Updated: Oct 26, 2025

The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress
Published on: July 4, 2013
Uncovering the structure of antagonism
Chelsea E Sleep1, Michael L Crowe1, Nathan T Carter1
1University of Georgia.
Abstract:
Despite the advances in our understanding of the structure of personality and psychopathology (see Kotov et al., 2017), less attention has been paid to empirically examining their underlying facet structure. To gain a more nuanced understanding of the structure of personality, it is important to identify empirically derived lower order structures of these trait domains; thus, the present study sought to examine the structure of antagonism as represented by items from commonly used measures of pathological personality traits. Participants were recruited from a large, southeastern university (N = 532) and completed 234 antagonism items selected from seven measures of pathological personality traits. Criterion variables measuring interpersonal adjectives, aggression, substance use, depression, and anxiety were also collected. A series of factor analyses were conducted to examine the structure of antagonism at a range of specificities. A seven-factor solution emerged as being both comprehensive and reasonably parsimonious with factors labeled Callousness, Grandiosity, Domineering, Manipulation, Suspiciousness, Aggression, and Risk Taking. The present findings demonstrate how trait Antagonism unfolds at varying levels of specificity as well as how the emergent factors differentially relate to outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
More Related Videos
Related Concept Videos
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Drug-Receptor Interaction: Antagonist
Antagonists can be classified as competitive or noncompetitive based on their...
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Agonism and Antagonism: Quantification
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Drug-Receptor Interactions
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....

