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Dopaminergic supersensitivity after long-term bromopride treatment
L F Felicio1, A G Nasello, J Palermo-Neto
1Clinical Pharmacology and Toxicology, School of Veterinary Medicine, University of São Paulo, Brazil.
Abstract:
The effects of bromopride administration on open-field and apomorphine-induced stereotyped behavior of rats were studied. Bromopride induced a displacement to the right of the control dose-response curve constructed for apomorphine stereotypes. Withdrawal from long-term bromopride treatment induced not only a significant increase in ambulation and rearing frequencies for male rats observed in the open-field but also an increased sensitivity of both male and female animals to apomorphine. The results are interpreted as a consequence of the development of supersensitivity of central dopaminergic receptors, probably of the mesostriatal pathways.