Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

480
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
480
Seizures: Classification01:13

Seizures: Classification

802
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
802
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

547
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
547
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

607
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
607

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A practical framework for discussing sudden unexpected death in epilepsy with patients and families: Resolving the communication gap.

Epilepsia·2026
Same author

A Phase 1 Study of Convection-Enhanced Delivery of Intraputaminal AAV2-GDNF in Advanced Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Factors associated with rapid pediatric acute seizure emergency treatment: Quality Improvement in Time to Treat Status Epilepticus baseline cohort.

Epilepsia·2026
Same author

Extracellular vesicles from wild-type Epstein-Barr virus-transformed B-cells export host DNA and EBV EBER1.

bioRxiv : the preprint server for biology·2026
Same author

Real-time, automated, standardized, and transparent analysis of microfluidic nanoparticle data with RPS<sub>PASS</sub>.

bioRxiv : the preprint server for biology·2026
Same author

Evaluation of potential serum biomarkers for individuals at risk of multiple sclerosis.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Oct 26, 2025

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

3.0K

Human herpesvirus 6 and epilepsy.

William H Theodore1, Emily Leibovitch1, Bridgette J Billioux1

  • 1Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.

Epilepsia Open
|July 29, 2021
PubMed
Summary

Human herpesvirus 6 (HHV-6) DNA was detected in brain tissue from patients with mesial temporal sclerosis (MTS). This suggests HHV-6 may play a role in causing MTS, a common epilepsy condition.

Keywords:
HHV-6focal epilepsymesial temporal sclerosis

More Related Videos

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

74.8K
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

17.6K

Related Experiment Videos

Last Updated: Oct 26, 2025

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
05:33

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Published on: June 23, 2022

3.0K
Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

74.8K
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

17.6K

Area of Science:

  • Neurovirology
  • Epileptology
  • Neuropathology

Background:

  • Mesial temporal sclerosis (MTS) is a common cause of drug-resistant epilepsy.
  • The etiology of MTS remains incompletely understood.
  • Human herpesvirus 6 (HHV-6) is a neurotropic virus with suspected links to neurological disorders.

Purpose of the Study:

  • To investigate the association between HHV-6 infection and mesial temporal sclerosis (MTS) in patients undergoing epilepsy surgery.
  • To determine if HHV-6 is present in brain tissue of patients with MTS and other neuropathologies.
  • To explore potential inflammatory markers associated with HHV-6 in epilepsy foci.

Main Methods:

  • Analysis of brain tissue DNA from 87 epilepsy surgery patients using quantitative real-time PCR and digital droplet PCR for HHV-6A and HHV-6B.
  • Histopathological examination of brain tissue using H&E, GFAP, and NeuN stains.
  • Positron emission tomography (PET) with [11C]PBR28 in a subset of patients to assess neuroinflammation.

Main Results:

  • HHV-6 DNA was detected in 29/54 patients with MTS, 6/23 with focal cortical dysplasia (FCD), and 1/3 with a history of encephalitis (P < .02).
  • Patients with MTS exhibited a significantly earlier seizure onset age compared to those with other pathologies.
  • A trend towards higher [11C]PBR28 binding in seizure foci of HHV-6 positive patients suggested increased neuroinflammation.

Conclusions:

  • The findings support a potential etiological role for human herpesvirus 6 (HHV-6) in the development of mesial temporal sclerosis (MTS).
  • HHV-6 detection in MTS tissue warrants further investigation into its pathogenic mechanisms in epilepsy.
  • Neuroinflammation may be a contributing factor in HHV-6 associated MTS.