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Homo/Heteropentanuclear Porphyrazine Mg^II, Zn^II, and Pd^II Macrocycles with Externally Pending PdCl₂ and Pd(CBT)₂

Noemi Bellucci¹, Maria Pia Donzello¹, Elisa Viola¹

¹Dipartimento di Chimica, Università degli Studi di Roma Sapienza, P. le A. Moro 5, I-00185 Rome, Italy.

Inorganic Chemistry

|July 29, 2021

Abstract:

Recent work has been developed on two new classes of neutral porphyrazine complexes of formulas [(PdCl₂)₄Py₈PzM]·xH₂O (Py₈Pz = octakis(2-pyridyl)porphyrazinato anion; M = Mg^II(H₂O), Zn^II, Pd^II) and [{Pd(CBT)₂}₄Py₈PzM]·xH₂O (M = Mg^II(H₂O), Zn^II; CBT = m-carborane-1-thiolate anion). Characterization of all the species has been conducted by IR and UV-visible spectral measurements in a systematic comparison with the corresponding already known mononuclear species [Py₈PzM] (M = Mg^II(H₂O), Zn^II) and the mono-Pd^II analogue isolated and presented here for the first time. Comparison includes also the two parent classes of pentanuclear tetrapyrazinoporphyrazines having the more extended π-electron delocalized macrocyclic core Py₈TPyzPz. The reported new classes of pentanuclear complexes behave as active photosensitizers in photodynamic therapy (PDT), and due to the high boron content of the CBT derivatives, perspectives for them are open of application in the field of bimodal PDT/BNCT (boron neutron capture therapy) anticancer treatments.

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