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Comparisons between retinal vessel calibers and various optic disc morphologic parameters with different optic disc
Kazunobu Sugihara1, Yasuyuki Takai1, Ryo Kawasaki2
1Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan.
Plos One
|July 29, 2021
Summary
Glaucoma Stereo Analysis Study findings show retinal vessel caliber variations correlate with optic nerve head changes and visual field scores. These associations differ across distinct optic disc appearances, indicating varied impacts of vascular changes in glaucoma.
Area of Science:
- Ophthalmology
- Medical Imaging
- Vascular Biology
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Optic nerve head (ONH) morphology and retinal vasculature are critical in glaucoma assessment.
- Understanding the relationship between ONH parameters and retinal vessel calibers is essential for early diagnosis and management.
Purpose of the Study:
- To comprehensively evaluate retinal vessel calibers and their correlations with 38 optic nerve head (ONH) morphologic parameters in glaucoma patients.
- To investigate how these associations differ among various optic disc appearances.
- To confirm the effect of retinal vessel narrowing on glaucomatous changes.
Main Methods:
- Utilized stereo fundus photographs from the Glaucoma Stereo Analysis Study (GSAS), a multicenter collaborative study.
- Analyzed retinal vessel calibers, specifically central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE).
- Correlated vessel calibers with 38 ONH morphologic parameters and visual field scores across different optic disc types (focal ischemia, generalized enlargement, myopic glaucoma, senile sclerosis).
Main Results:
- Mean CRAE was 138.4 μm and CRVE was 216.5 μm in 240 eyes.
- CRAE correlated with age, visual field scores, and 19 ONH parameters.
- CRVE correlated with age, intraocular pressure, visual field scores, and 11 ONH parameters.
- CRVE was significantly narrower in senile sclerosis (SS) compared to focal ischemia (FI) and myopic glaucoma (MY).
- The associations between retinal vessel caliber and ONH parameters varied significantly across different optic disc appearances.
Conclusions:
- Retinal vessel caliber, particularly CRVE, shows distinct patterns in different glaucoma optic disc morphologies.
- The relationship between retinal vessel caliber and ONH parameters is not uniform across all glaucoma types.
- These findings highlight the differential impact of vascular changes in various optic disc appearances in glaucoma.
