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Long-term effects of coronavirus disease 2019 on the cardiovascular system, CV COVID registry: A structured summary
Victor Arévalos1, Luis Ortega-Paz1, Diego Fernandez-Rodríguez2
1Department of Cardiology, Clinic Cardiovascular Institute, Hospital Universitari Clinic, Barcelona, Spain.
Insights
Patients with COVID-19 face unknown long-term cardiovascular risks. This registry tracks cardiovascular outcomes in patients tested for SARS-CoV-2 to understand these long-term effects.
Area of Science:
- Cardiology
- Infectious Diseases
- Epidemiology
Background:
- Coronavirus disease 2019 (COVID-19) patients exhibit high risks for cardiovascular adverse events.
- Long-term cardiovascular consequences for COVID-19 survivors remain largely uncharacterized.
- Understanding these outcomes is critical for patient management and public health.
Purpose of the Study:
- To establish a registry of patients tested for SARS-CoV-2.
- To determine the long-term cardiovascular outcomes in individuals with and without COVID-19.
- To compare cardiovascular mortality and morbidity between COVID-19 positive and negative groups.
Main Methods:
- Multicenter, observational, retrospective registry.
- Inclusion of adult patients undergoing RT-PCR testing for SARS-CoV-2 (March-August 2020).
- Primary outcome: 1-year cardiovascular mortality; Secondary outcomes: myocardial infarction, stroke, heart failure, pulmonary embolism, arrhythmias.
Main Results:
- Data collection ongoing; results pending.
- The study aims to provide robust data on cardiovascular events at one year post-testing.
- Comparison between COVID-19 positive and negative cohorts will elucidate disease-specific risks.
Conclusions:
- The registry will enhance understanding of the long-term cardiovascular implications of COVID-19.
- Findings will inform clinical practice and strategies for managing cardiovascular health in post-COVID-19 patients.
- This research addresses a critical knowledge gap in the sequelae of SARS-CoV-2 infection.
Background:
Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who have undergone a diagnostic nasopharyngeal swab for SARS-CoV-2 and to determine their long-term cardiovascular outcomes.
Study And Design:
This is a multicenter, observational, retrospective registry to be conducted at 17 centers in Spain and Italy (ClinicalTrials.gov number: NCT04359927). Consecutive patients older than 18 years, who underwent a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV2 in the participating institutions, will be included since March 2020, to August 2020. Patients will be classified into two groups, according to the results of the RT-PCR: COVID-19 positive or negative. The primary outcome will be cardiovascular mortality at 1 year. The secondary outcomes will be acute myocardial infarction, stroke, heart failure hospitalization, pulmonary embolism, and serious cardiac arrhythmias, at 1 year. Outcomes will be compared between the two groups. Events will be adjudicated by an independent clinical event committee.
Conclusion:
The results of this registry will contribute to a better understanding of the long-term cardiovascular implications of the COVID19.
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