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Topological network based drug repurposing for coronavirus 2019.

Mahnaz Habibi1, Golnaz Taheri2,3

  • 1Department of Mathematics, Qazvin Branch, Islamic Azad University, Qazvin, Iran.

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Summary
This summary is machine-generated.

This study identifies human proteins that bind to approved drugs for treating COVID-19. The research highlights potential drug candidates and essential proteins involved in disease pathology, aiding future therapeutic development.

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Area of Science:

  • * Computational biology
  • * Bioinformatics
  • * Drug discovery

Background:

  • * The COVID-19 pandemic necessitates rapid identification of effective treatments.
  • * Existing drug discovery pipelines are slowed by clinical trial durations and incomplete understanding of SARS-CoV-2.
  • * Repurposing approved drugs offers a faster route to potential COVID-19 therapies.

Purpose of the Study:

  • * To identify a subset of human proteins that can bind to approved drugs for COVID-19 treatment.
  • * To analyze host-virus protein interactions and their impact on cellular processes.
  • * To identify key proteins essential for COVID-19 pathology and associated comorbidities.

Main Methods:

  • * Analyzing human-virus protein interactions and host cell biological processes.
  • * Defining topological and statistical features of proteins within a protein-protein interaction network.
  • * Evaluating selected protein sets against experimental and clinical trial COVID-19 drugs using DAVID tools.
  • * Investigating shared genes among COVID-19 comorbidities.

Main Results:

  • * Selected protein sets showed high overlap with experimental (15/17) and clinical trial (85%) COVID-19 drugs.
  • * Identified essential proteins crucial for COVID-19 pathology.
  • * Revealed significant enrichment of shared genes in cardiovascular, hypertension, diabetes type 2, kidney, and lung diseases.
  • * Recommended 56 potential drugs for further investigation.

Conclusions:

  • * The study successfully identified human protein targets for drug repurposing against COVID-19.
  • * The findings provide a foundation for developing targeted therapies by understanding host-pathogen interactions.
  • * Identified comorbidities suggest potential therapeutic strategies for patients with multiple health conditions.