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An objective marker of lactate-induced panic.
J M Gorman1, M Davies, R Steinman
1Biological Studies Unit, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, NY.
Psychiatry Research
|December 1, 1987
Summary
Researchers developed a new heart rate index (HRI) to objectively measure panic attacks during laboratory studies. This index correlates with subjective panic experiences and aids in standardizing panic provocation research.
Area of Science:
- Psychiatry
- Cardiology
- Neuroscience
Background:
- Laboratory studies on panic attacks often rely on subjective assessments.
- A need exists for objective measures to standardize panic provocation research.
Purpose of the Study:
- To develop an objective index for quantifying panic attacks during laboratory provocation.
- To assess the correlation between heart rate changes and subjective panic experiences.
Main Methods:
- Sodium lactate infusions were administered to participants.
- Heart rate (HR) recordings were collected during infusions.
- A novel formula, the heart rate index (HRI), was developed using HR data.
- Heart rate variability was analyzed using the successive difference mean square statistic.
Main Results:
- The developed heart rate index (HRI) showed a strong correlation with the subjective experience of panic.
- The HRI was most effective in identifying panic attacks within the first 15 minutes of 20-minute infusions.
- No significant changes in heart rate variability were observed during lactate-induced panic attacks.
Conclusions:
- The heart rate index (HRI) offers a promising objective measure for panic attacks in laboratory settings.
- Tachycardia during lactate-induced panic is unlikely to be solely due to decreased vagal tone.
- Further research can utilize the HRI to standardize and advance panic disorder studies.