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Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
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Effect of methylphenidate as a dopaminergic agent on myopia: Pilot study
Ugur Gurlevik1, Halil Kara2, Erdogan Yasar1
1Department of Ophthalmology, Aksaray University Faculty of Medicine, Aksaray Education and Research Hospital, Aksaray, Turkey.
International Journal of Clinical Practice
|July 29, 2021
Summary
Methylphenidate (MPH) treatment for ADHD did not significantly alter refractive error or axial length in children over 12 months. However, MPH may potentially slow myopia progression, as indicated by a lack of change compared to a control group experiencing significant myopic shifts.
Area of Science:
- Ophthalmology
- Pediatrics
- Pharmacology
Background:
- Methylphenidate (MPH) is a first-line ADHD treatment, but concerns exist regarding its impact on refractive disorders.
- Myopia is increasing globally, particularly in children, linked to environmental factors and genetics.
- Dopamine's role in myopia development is supported by animal studies, suggesting potential therapeutic targets.
Purpose of the Study:
- To investigate the effect of MPH therapy on myopic shifts in refraction in children diagnosed with ADHD.
- To compare refractive changes in children with ADHD treated with MPH against a matched control group.
Main Methods:
- A prospective study involving children with ADHD undergoing MPH treatment.
- Cycloplegic refraction and axial length measurements were taken at baseline and 12 months.
- An age-gender-matched control group with no ADHD or MPH treatment was included for comparison.
Main Results:
- No statistically significant changes in spherical equivalent or axial length were observed in the MPH group over 12 months.
- The control group exhibited statistically significant increases in both spherical equivalent and axial length.
- Patient demographics: 19 children (57.9% female, mean age 11.3 ± 2 years).
Conclusions:
- Twelve-month MPH use did not lead to significant myopic shifts or changes in axial length in children with ADHD.
- The observed lack of myopic progression in the MPH group, contrasted with the control group, suggests MPH might mitigate myopia.
- This pilot study supports further research into dopamine's potential role in managing myopia progression.
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