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Clinical translation of immunomodulatory therapeutics

Amanda Nash1, Samira Aghlara-Fotovat1, Andrea Hernandez1

  • 1Rice University, Department of Bioengineering, Houston TX, United States.

Advanced Drug Delivery Reviews
|July 29, 2021
PubMed

Immunomodulatory therapeutics represent a unique class of drug products that have tremendous potential to rebalance malfunctioning immune systems and are quickly becoming one of the fastest-growing areas in the pharmaceutical industry. For these drugs to become mainstream medicines, they must provide greater therapeutic benefit than the currently used treatments without causing severe toxicities. Immunomodulators, cell-based therapies, antibodies, and viral therapies have all achieved varying amounts of success in the treatment of cancers and/or autoimmune diseases. However, many challenges related to precision dosing, off-target effects, and manufacturing hurdles will need to be addressed before we see widespread adoption of these therapies in the clinic. This review provides a perspective on the progress of immunostimulatory and immunosuppressive therapies to date and discusses the opportunities and challenges for clinical translation of the next generation of immunomodulatory therapeutics.

Keywords:
AntibodiesCell therapyCytokinesDrug deliveryImmunomodulationImmunotherapyRegulatory considerations

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