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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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Can Covid-19 attack our nervous system?

Sara Mohamed Naguib Abdel Hafez1

  • 1Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Egypt.

Journal of Chemical Neuroanatomy
|July 29, 2021
PubMed
Summary
This summary is machine-generated.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can invade the central nervous system (CNS), causing neurological symptoms. This review explores the virus

Keywords:
CNSCOVID-19SARS-CoV-2

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Area of Science:

  • Neuroscience
  • Virology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, primarily affects the respiratory system.
  • Emerging evidence indicates SARS-CoV-2 can also impact the nervous system, leading to diverse neurological manifestations.
  • Understanding these neurological effects is crucial for managing COVID-19 patients.

Purpose of the Study:

  • To review the potential mechanisms of SARS-CoV-2 entry into the central nervous system (CNS).
  • To discuss the pathophysiology of neuroinvasion by SARS-CoV-2.
  • To highlight the neurological symptoms and signs associated with COVID-19.

Main Methods:

  • Literature review of studies investigating SARS-CoV-2 neuroinvasion.
  • Analysis of proposed pathways for viral entry into the CNS.
  • Synthesis of reported neurological findings in COVID-19 patients.

Main Results:

  • SARS-CoV-2 can access the CNS through the bloodstream, infecting endothelial cells.
  • The virus may enter the peripheral nervous system via retrograde neuronal pathways.
  • Viral entry into synapses, retrograde transport, and trans-synaptic spread are potential mechanisms.

Conclusions:

  • SARS-CoV-2 possesses multiple routes to invade the CNS.
  • Neuroinvasion contributes to the diverse neurological complications observed in COVID-19.
  • Further research is needed to fully elucidate SARS-CoV-2 pathophysiology in the nervous system.