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Related Experiment Videos

Endocrine and physiological changes during "spontaneous" panic attacks.

O G Cameron1, M A Lee, G C Curtis

  • 1Department of Psychiatry, University of Michigan Medical Center, Ann Arbor 48109.

Psychoneuroendocrinology
|January 1, 1987
PubMed
Summary

Panic attacks in patients showed elevated plasma prolactin, correlating with severity. Other hormonal and physiological changes were inconsistent, suggesting prolactin as a key indicator during panic episodes.

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Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Human Physiology

Background:

  • Panic disorder is a significant psychiatric condition characterized by recurrent, unexpected panic attacks.
  • Understanding the physiological underpinnings of panic attacks is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate hormonal and physiological responses during spontaneous panic attacks.
  • To compare these responses between patients with panic disorder and healthy controls.

Main Methods:

  • Eight patients meeting DSM-III criteria for panic attacks and four healthy subjects were monitored.
  • Hormonal variables (prolactin, cortisol, growth hormone, epinephrine, norepinephrine, MHPG) and heart rate were measured at set intervals over 24 hours and during spontaneous attacks.

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Main Results:

  • No significant differences in hormonal levels were observed at predetermined times, except for reduced urinary unconjugated epinephrine in patients.
  • Plasma prolactin levels were elevated at the peak of most panic attacks, correlating with symptom severity.
  • Plasma cortisol, growth hormone, and heart rate showed transient elevations during some attacks; plasma norepinephrine increased slightly.

Conclusions:

  • Plasma prolactin elevation appears to be a significant physiological marker during panic attacks.
  • Most other measured hormonal and physiological variables did not show consistent or significant changes during panic attacks in this study.