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Updated: Oct 26, 2025
Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
Exercise training improves participation in persons with multiple sclerosis: A systematic review and meta-analysis
Thomas Edwards1, Anne Sophie Michelsen2, Afolasade O Fakolade3
1School of Human Kinetics, University of Ottawa, Ottawa, ON K1N6N5, Canada.
Exercise training significantly improves participation in daily life for individuals with multiple sclerosis (MS). This review highlights exercise
Area of Science:
- Neurology
- Rehabilitation Science
- Exercise Physiology
Background:
- Previous research on exercise training in multiple sclerosis (MS) has focused on various International Classification of Functioning, Disability and Health (ICF) components, but its impact on participation remains under-explored.
- Understanding the effects of exercise on participation is crucial for improving the quality of life for individuals with MS.
Purpose of the Study:
- To systematically review outcome measures assessing participation in exercise training studies for people with MS.
- To quantitatively evaluate the impact of exercise training on participation levels in individuals with MS.
Main Methods:
- A comprehensive literature search across six electronic databases identified relevant controlled and noncontrolled trials.
- International Classification of Functioning, Disability and Health (ICF) linking rules were applied to identify participation-related outcome measures.
- Meta-analysis of 23 randomized controlled trials quantified the effect of exercise training on participation.
Main Results:
- The systematic review identified 16 outcome measures covering all 9 ICF participation chapters, with mobility being the most frequently assessed.
- A meta-analysis of 23 randomized controlled trials revealed a moderate, positive effect of exercise training on participation (effect size = 0.60).
- Exercise training demonstrated a statistically significant positive impact on participation outcomes (p < 0.001).
Conclusions:
- This review offers guidance for selecting appropriate outcome measures to assess participation in MS exercise studies.
- Exercise training positively influences participation outcomes, supporting its role in enhancing engagement in everyday activities for individuals with MS.
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