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Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
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Virus discovery in chronic inflammatory demyelinating polyneuropathy
G G A van Lieverloo1, L Wieske1, I N van Schaik2
1Amsterdam UMC, Department of Neurology, Amsterdam, the Netherlands.
Journal of Neuroimmunology
|July 29, 2021
Summary
A viral infection is unlikely to cause chronic inflammatory demyelinating polyneuropathy (CIDP). Researchers analyzed patient samples using advanced virus detection, finding no evidence of persistent viral infections linked to CIDP.
Area of Science:
- Neurology
- Virology
- Immunology
Background:
- The triggers for chronic inflammatory demyelinating polyneuropathy (CIDP), an autoimmune disorder, remain unknown.
- Viral infections are suspected contributors to CIDP, similar to Guillain-Barré syndrome (GBS).
Purpose of the Study:
- To investigate the potential role of viral infections in the pathogenesis of CIDP.
- To compare the virome in CIDP patients with GBS patients and healthy controls.
Main Methods:
- Utilized VIDISCA-next generation sequencing for comprehensive virus detection.
- Analyzed serum samples from 47 CIDP patients, 24 GBS patients, and 114 healthy controls.
- Examined cerebrospinal fluid (CSF) from 17 CIDP patients.
Main Results:
- Anelloviruses were detected in CIDP (10.6%), GBS (42%), and healthy controls (28.1%), generally considered non-pathogenic.
- Parvovirus B19 and GB virus C were found in a small percentage of CIDP and GBS samples.
- No other viral sequences were identified in serum or CSF, and viral detection in CSF was likely due to contamination.
Conclusions:
- A persistent viral infection sustaining the autoimmune response in CIDP appears unlikely.
- The study suggests viral triggers are not a primary cause of CIDP.
