Related Experiment Video
Updated: Oct 26, 2025

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
Published on: December 8, 2023
A Novel Topical Treatment for Keratosis Obturans
Max Zwemstra1, Fenna Ebbens, Maarten de Wolf
1Department of Otorhinolaryngology, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands.
Objective:
To present and evaluate the treatment of keratosis obturans (KO) using miconazole/triamcinolone 0.1% crème gauzes.
Study Design:
A retrospective clinical capsule report.
Patients:
Twelve patients diagnosed with KO between January 2000 and July 2020 visiting our tertiary hospital setting, were retrospectively reviewed.
Interventions:
Either miconazole/triamcinolone 0.1% crème gauzes or periodic microscopic removal of the keratin plug.
Main Outcome Measures:
No evidence of disease during microscopic inspection of the ear canal.
Results:
Successful treatment with miconazole/triamcinolone 0.1% gauzes was seen in 4/7 patients (57%) and successful treatment of periodic cleaning of the ear canal was seen in 1/5 patients (20%).
Conclusions:
Topical treatment of KO with miconazole/triamcinolone 0.1% crème gauzes in the ear canal could be considered as a treatment option for patients diagnosed with KO.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Clinical Applications of Epidermal Stem Cells
Hand hygiene
Hand washing...
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Renewal of Skin Epidermal Stem Cells

