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Related Experiment Video

Updated: Oct 26, 2025

Microvascular Decompression: Salient Surgical Principles and Technical Nuances
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Microvascular Decompression for Trigeminal Neuralgia: A Prospective, Multicenter Study.

Yoshifumi Mizobuchi1, Shinji Nagahiro1, Akinori Kondo2

  • 1Department of Neurosurgery, Faculty of Medicine, Tokushima University, Tokushima, Japan.

Neurosurgery
|July 29, 2021
PubMed

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Summary
This summary is machine-generated.

Microvascular decompression (MVD) offers effective long-term relief for trigeminal neuralgia (TGN). This multicenter study confirms MVD

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Research

Background:

  • Microvascular decompression (MVD) is recognized as the most effective long-term treatment for trigeminal neuralgia (TGN).
  • Existing evidence primarily comes from retrospective and single-center studies, lacking prospective, multicenter validation.

Purpose of the Study:

  • To prospectively evaluate the short- and long-term outcomes of MVD in TGN patients.
  • To assess complication rates associated with MVD at specialized Japanese institutions.

Main Methods:

  • A prospective, multicenter study involving 166 TGN patients undergoing MVD between April 2012 and March 2015.
  • Facial pain and complication data were collected at 7 days, 1 year, and 3 years postoperatively.
  • Neuromonitoring was utilized in 84.3% of cases.
Keywords:
Elderly patientsMicrovascular decompressionMulticenter studyProspective studyTrigeminal neuralgia

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Main Results:

  • Short-term complete pain relief was achieved in 78.9% of patients, with a 0% mortality rate and a 16.3% complication rate.
  • Long-term follow-up (3 years) included 155 patients (93.4%), reporting 80.0% complete pain relief and a significantly reduced complication rate of 5.2%.
  • The study included a substantial proportion of elderly patients (105 over 60 years).

Conclusions:

  • MVD demonstrates high long-term efficacy and curative potential for TGN when performed by experienced neurosurgeons.
  • Complications associated with MVD are generally uncommon and transient.
  • MVD is confirmed as a safe and effective treatment option for TGN, including in the elderly population.