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Pan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers

Yuting He1,2,3,4, Xiao Yu5,6,7,8, Menggang Zhang5,6,7,8

  • 1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Road, Zhengzhou, 450052, China. fccheyt1@zzu.edu.cn.

World Journal of Surgical Oncology
|July 30, 2021
PubMed
Abstract

Insights

Mutations in 5-methylcytosine (m5C) regulators are linked to cancer development and poor patient outcomes. Understanding these m5C alterations is crucial for cancer research.

Area of Science:

  • Epigenetics and Cancer Biology
  • RNA and DNA Modifications

Background:

  • 5-Methylcytosine (m5C) is a critical reversible epigenetic modification in DNA and RNA.
  • The role of m5C modifications and their regulators in human cancer remains largely undefined.
  • Understanding m5C dysregulation is essential for cancer pathogenesis and progression insights.

Purpose of the Study:

  • To investigate the correlation between m5C regulatory gene alterations and cancer development.
  • To assess the impact of m5C regulator expression on cancer hallmark pathways.
  • To determine the clinical significance of m5C regulator alterations in human tumors.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) database for comprehensive analysis.
  • Analyzed mutations and copy number variations (CNVs) in m5C regulatory genes across diverse cancer types.
  • Correlated m5C regulator expression with the activity of cancer hallmark pathways.

Main Results:

  • Identified significant correlations between m5C gene mutations/CNVs and various cancer types.
  • Observed upregulation of m5C regulators in tumor-specific processes, linking them to cancer progression.
  • Demonstrated that aberrant alterations in m5C regulatory genes are associated with poor clinical outcomes in multiple cancers.

Conclusions:

  • Provided strong evidence for the involvement of m5C regulators in cancer pathogenesis and survival.
  • Highlighted the clinical implications of m5C regulator alterations, suggesting their potential as biomarkers or therapeutic targets.
Keywords:
5-MethylcytosineFrequent network miningPan-cancer analysisSurvivalm5C regulatory genes

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