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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
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Genomic DNA in Eukaryotes00:58

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Oct 26, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

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GenoVault: a cloud based genomics repository.

Sankalp Jain1, Amit Saxena1, Suprit Hesarur1

  • 1HPC-M&BA) Group, Centre for Development of Advanced Computing (C-DAC), Pune, MH, 411008, India.

Biodata Mining
|July 30, 2021
PubMed
Summary
This summary is machine-generated.

GenoVault offers a secure, scalable, cloud-based repository for Next Generation Sequencing (NGS) data management. It utilizes object storage and an OpenStack private cloud for efficient handling and sharing of sensitive genomic data.

Keywords:
CloudGenomics repositoryNGSOpenStack

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Data Science

Background:

  • Next Generation Sequencing (NGS) generates vast amounts of data requiring robust management solutions.
  • Existing data repositories may lack the scalability, security, or specific features needed for sensitive, unpublished genomic data.
  • Effective organization and sharing of institutional NGS data are crucial for research and collaboration.

Purpose of the Study:

  • To introduce GenoVault, a novel cloud-based repository system for Next Generation Sequencing (NGS) data.
  • To provide a scalable, secure, and user-friendly platform for managing and sharing diverse NGS data types.
  • To leverage OpenStack private cloud infrastructure for efficient and flexible data handling.

Main Methods:

  • Development of GenoVault on an OpenStack-based private cloud utilizing services like Keystone, Cinder, Neutron, and Nova.
  • Implementation of object-based storage for faster data retrieval compared to traditional file or block storage.
  • Integration of a web-based interface and a JavaFX desktop client to support large file uploads and user accessibility.
  • Utilizing metadata for database querying and implementing Secure File Transfer Protocol (SFTP) for secure data transfer.

Main Results:

  • GenoVault enables efficient storage and retrieval of various NGS data formats (FASTQ, BAM, SAM, BED, VCF).
  • The system supports both public data sharing and private access control, ensuring data security.
  • Scalability is achieved through OpenStack features, allowing for vertical and horizontal expansion.
  • Data integrity and authentication are verified before data sharing, enhancing collaborative research.

Conclusions:

  • GenoVault provides a robust solution for managing and sharing unpublished, organization-wide NGS data.
  • The platform facilitates collaboration among institutions by enabling secure data exchange.
  • GenoVault is a valuable tool for bioinformatics research, offering a scalable and secure alternative to public repositories for sensitive data.